Tablets

Two

members of the new class of drugs reduces

joint damage associated with rheumatoid arthritis. Rheumatoid arthritis

(RA) is an inflammatory disease that causes pain, swelling, stiffness

, and progressive loss of function in joints. Two studies published in the New England Journal of Medicine estimated

effectiveness of inhibitors of TNF, drugs that neutralize

inflammatory protein, known as

tumor necrosis factor (TNF). TNF in excessive quantities in the joints of patients with rheumatoid arthritis

and is believed responsible for most of >> << joint damage in RA. In one study conducted at Johns Hopkins University in Baltimore

, etanertsept (Enbrel) was compared with methotrexate in 632

patients with early-stage rheumatoid arthritis. Etanertsept

acted more quickly to decrease symptoms than methotrexate. In addition, etanertsept was more effective in slowing the progress >> << joint erosion, velocity joint damage, measured

X-rays, was significantly reduced in etanertsept group in comparison with the

methotrexate group. After one year of treatment, 72

etanertsept percent of patients had no progress in joint erosion >> << compared with 60 percent of the methotrexate patients.

The second study conducted at the University of Texas

Medical Center in Dallas, and 428 patients with chronic

active rheumatoid arthritis for 12 months. Researchers >> << found that the combination of TNF inhibitors ynflyksymab (Remykeyd)

and methotrexate significantly reduce symptoms of rheumatoid arthritis and

stop the progression of joint damage compared to methotrexate treatment

only. Approximately 52 percent of patients receiving

ynflyksymab and methotrexate combination showed symptom reduction >> << compared to only 17 percent methotrexate patients. X-ray examination showed that joint damage stopped in

patients receiving the drug combination. In addition, joint damage

declined to 40-55 percent of patients on combination therapy, which means

, that some damage was repaired. Meanwhile, joint damage

progressed to the group that received only methotrexate. Combination therapy

, which is well tolerated and significantly improved quality of life

. Methotrexate, the standard treatment of rheumatoid arthritis

was approved by more than a decade ago to treat certain types of arthritis

and skin diseases. However, it can cause serious side effects

, including liver damage. In contrast, both inhibitors of TNF

well. An estimated one percent of the adult U.S. population has rheumatoid arthritis

, and is about two to three times more common in

women than men. The new

Medicines approved for the treatment of eczema Atopic dermatitis is a chronic, inherited skin disease

causes redness what are the side effects of lasix, itching and discharge damage.

It mainly affects children

but can survive in adulthood. Doctors often prescribe oral or

corticosteroids for severe cases. But while steroids

very effective in soothing inflammation, they may have adverse effects >> << parties. Steroid creams can cause thinning of the skin and

decreased collagen production, and oral corticosteroids may be

more serious side effects. Now dermatologists have great hopes for a new tacrolimus ointment

(Protopic), which was recently approved by the FDA for the treatment of moderate-severe eczema >> << patients who can not tolerate or do not adequately assist standard

treatments. FDA has approved tacrolimus-based

with three 12-week study in which 90% improvement in

one-third of patients who used drugs. Two additional one year

research and reviewed FDA, has shown that adults

, who used the drug intermittently during the year was

no side effects except temporary burning and stinging. For

tacrolimus may increase sensitivity to ultraviolet (UV)

users should avoid sunshine, tanning, and treatment with UVA

or UV light. Corticosteroids are very effective in reducing inflammation. These drugs

may be taken in many forms: injected directly into >> << shoulder to treat tendonitis, inhaled into the lungs to calm inflammation

characteristic of asthma, or in the form of creams to treat skin rash. Tablets

form (usually prednisone, prednisolone) may be used for

treatment of diseases such as arthritis or lupus. One of the serious side effects

while taking these drugs for long periods is loss of bone mass

fact, osteoporosis. Bisphosphonates drugs (use

to treat osteoporosis) has been shown to prevent bone loss associated with

corticosteroids. Recent studies have confirmed that the new

developed bisphosphonates, ryzedronat helped prevent bone loss associated with

use of steroids. While improved treatment ryzedronat

bone mineral density is too early to tell for sure if it

can reduce fracture among patients on steroids. .